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pentobarbital will lessen the level or effect of phenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep an eye on.pentobarbital will minimize the level or effect of alosetron by influencing hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Unknown.pentobarbital will lessen the extent or effect of fludrocortisone